Although natural hallucinogenic drugs were known to man for millennia, it was in the early twentieth century that they received broad attention from the West (MobileReference, 2009). Among earlier inventions are the late 18th century scientific studies of nitrous oxide and late 19th century studies of the components of the peyote cactus. In 1927, Kurt Beringer studied the Mescaline Intoxication, laying a foundation for studying psychoactive plants (MobileReference, 2009). Subsequently, in 1928 Louis Lewin did publish his comprehensive survey on Phantastica. Subsequent developments incorporated Robert J. Weitlaner’s re-discovery of Mexican magic mushrooms in 1936, and Richard Evans Schultes discovery of ololiuhqui in 1939. The most significant pre-World War II development was in 1938 when Albert Hofmann invented the semi-synthetic drug, LSD, which was later discovered to generate hallucinogenic effects, in 1943.