MR Spectroscopy

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1. Discuss the characteristics of surface coil localisation, including advantages and disadvantages of this technique.,
2. Discuss the relative merits of the PRESS and STEAM techniques, in particular the effect on signal-to-noise of both: (a) longitudinal (T1); and (b) spin-spin (T2) relaxation.,
3. Discuss the following statement: ‘Peak area is a direct measure of metabolite concentration’.,
4. Select from the literature an example of a neurological disorder which has been investigated by MRS. Briefly describe the pulse sequence used and the results obtained, in terms of spectral changes which may be characteristic for this disorder. Comment on the contribution of MRS to diagnosis and treatment of the disorder, and its efficacy in routine application.
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