This paper will focus on the use and misuse of substances that have a strong impact on the mood or performance of an individual. Initially, these drugs were prescribed to treat different forms of mental illnesses and depression. Numerous reports indicate that nowadays, these drugs are used for enhancement purposes (for example, it has been argued that individuals without any psychiatric illnesses could benefit from the use of such drugs – these substances elevate mood, motivation, attention, energy, etc.) Drug enhancers raise several ethical issues: The problem of self-understanding: this issue is closely related to identity and personality, authenticity, emotions, and temperament. The unfair advantage of those who are perfectly healthy, but who are taking these drugs for enhancement purposes only. Safety: the long-term effects of these drugs are unknown. Paper must be fully referenced.